Abstract

An emerging view suggests that exosomes (EVs) from therapy-induced senescent cancer cells may drive tumor progression and chemoresistance by inducing paracrine senescence in neighboring cells. Using a lung cancer cellular model, we will high-throughput investigate the proteomic and miRnomic content of early and late senescence-associated exosomes and SASP. The objectives include identifying EV proteins influencing DNA damage response signaling and microenvironment inflammation in chemoresistance, discovering exosome-contained miRNAs and their targets as well as cytokines and chemokines able to sustain cancer chemoresistance and modulating the tumor microenvironment.

Partenariato

• Università degli Studi di Udine
• Consiglio Nazionale delle Ricerche (CNR) Napoli
• Università degli Studi di Napoli Federico II

Importo del progetto

Importo totale del progetto        Euro 222.007,00
Importo del progetto Uniud        Euro 67.319,00
Finanziamento Uniud                Euro 0

Durata

• Dal 05.10.2023
• Al 04.10.2025