STIMOLA CURIOSITA’, PASSIONE E CORAGGIO
OCT4TME - Reprogramming the ovarian tumor microenvironment by interfering with epigenetic self-renewal circuits centered on OCT4 and trans-acting OCT4 pseudogene lncRNA
Abstract
Epithelial ovarian cancer (EOC), a lethal gynecological cancer, lacks universal therapy. OCT4, regulated by lncRNA hOCT4P3, drives aggressiveness via self-renewal circuits. Our goals: 1. Stratify EOC specimens by hOCT4P3 and OCT4, defining tumor-micro-environment (TME) components. 2. Identify compounds reversing OCT4-driven TME programming. 3. Unravel OCT4-driven EOC cell-TME communication. 4. Define hOCT4P3 lncRNA-directed silencing complex mechanisms. 5. Map hOCT4P3 lncRNA target sites in EOC genome, understanding its role in modulating aggressiveness. Project promises insights into novel epigenetic mechanisms, disrupting tumor-promoting TME in EOC.
Partenariato
- Università degli studi di Udine
- Università degli studi di Trieste
Importo del progetto
Importo totale del progetto Euro 281.736,80
Importo del progetto Uniud Euro 91.600,00
Finanziamento Uniud Euro 15.161,00
Durata
- Dal 18.10.2023
- Al 17.10.2025
Link