STIMOLA CURIOSITA’, PASSIONE E CORAGGIO
G4-APTASTAT - Design, synthesis and investigations on new G-quadruplex aptamers against STAT3 and the interleukine-6 receptor
Abstract
The IL-6/JAK/STAT3 axis is hyperactivated in several cancers, including pancreatic PDAC, leading to an unfavourable clinical outcome. Given its role in promoting tumour cell proliferation and metastasis, targeting this axis is a promising strategy for cancer therapies. This project will utilise G4 oligonucleotide aptamers that can bind to and sequester STAT3 and IL6. To facilitate cellular delivery, the G4 aptamers will be encapsulated in POPC liposomes. Multi-omic approaches, including transcriptomics and genomics, will elucidate the mechanism of action of the G4 aptamers, while their efficacy in inhibiting cancer cell proliferation will be evaluated using both 2D and 3D cell culture systems.
Partenariato
- Università degli Studi di Napoli Federico II
- Università degli Studi di Udine
- Università degli Studi di Milano
Importo del progetto
Importo totale del progetto Euro 103.962,00
Importo del progetto Uniud Euro 66.222,00
Finanziamento Uniud Euro 37.740,00
Durata
- Dal 5/10/2023
- Al 4/10/2025
Link