Titolo: “Sex-specific DPYD pharmacogenomic markers of the fluoropyrimidines treatment safety and efficacy in colorectal cancer patients.”

Supervisore: Dr.ssa E. Cecchin

Pubblicazioni:

• De Mattia E, Canzonieri V, Polesel J, Mezzalira S, Dalle Fratte C, Dreussi E, Roncato R, Bignucolo A, Innocente R, Belluco C, Pucciarelli S, De Paoli A, Palazzari E, Toffoli G, Cecchin E. SMAD3 Host and Tumor Profiling to Identify Locally Advanced Rectal Cancer Patients at High Risk of Poor Response to Neoadjuvant Chemoradiotherapy. Front Pharmacol. 2021 Dec 24;12:778781. doi: 10.3389/fphar.2021.778781. PMID: 35002714; PMCID: PMC8740633.
• Mezzalira S, Toffoli G. The effects of sex on pharmacogenetically guided drug treatment. Pharmacogenomics. 2021 Oct;22(15):959-962. doi: 10.2217/pgs-2021-0088. Epub 2021 Sep 21. PMID: 34545749.
• Bignucolo A, Scarabel L, Mezzalira S, Polesel J, Cecchin E, Toffoli G. Sex Disparities in Efficacy in COVID-19 Vaccines: A Systematic Review and Meta-Analysis. Vaccines (Basel). 2021 Jul 27;9(8):825. doi: 10.3390/vaccines9080825. PMID: 34451950; PMCID: PMC8402482.
• Dalle Fratte C, Mezzalira S, Polesel J, De Mattia E, Palumbo A, Buonadonna A, Palazzari E, De Paoli A, Belluco C, Canzonieri V, Toffoli G, Cecchin E. A panel of tumor biomarkers to predict complete pathological response to neo-adjuvant treatment in Locally Advanced Rectal Cancer. Oncol Res. 2021 Jun 9. doi: 10.3727/096504021X16232280278813. Epub ahead of print. PMID: 34108073.
• Dal Bo M, De Mattia E, Baboci L, Mezzalira S, Cecchin E, Assaraf YG, Toffoli G. New insights into the pharmacological, immunological, and CAR-T-cell approaches in the treatment of hepatocellular carcinoma. Drug Resist Updat. 2020 Jul;51:100702. doi: 10.1016/j.drup.2020.100702. Epub 2020 Apr 19. PMID: 32371296.
• Mezzalira S, De Mattia E, Guardascione M, Dalle Fratte C, Cecchin E, Toffoli G. Circulating-Free DNA Analysis in Hepatocellular Carcinoma: A Promising Strategy to Improve Patients' Management and Therapy Outcomes. Int J Mol Sci. 2019 Nov 5;20(21):5498. doi: 10.3390/ijms20215498. PMID: 31694149; PMCID: PMC6861910.
• Roncato R, Dal Cin L, Mezzalira S, Comello F, De Mattia E, Bignucolo A, Giollo L, D'Errico S, Gulotta A, Emili L, Carbone V, Guardascione M, Foltran L, Toffoli G, Cecchin E. FARMAPRICE: A Pharmacogenetic Clinical Decision Support System for Precise and Cost-Effective Therapy. Genes (Basel). 2019 Apr 4;10(4):276. doi: 10.3390/genes10040276. PMID: 30987397; PMCID: PMC6523070.
• Elena De Mattia, Marco Silvestri, Jerry Polesel, Fabrizio Ecca, Silvia Mezzalira, Lucia Scarabel, Yitian Zhou, Hilde Rosing, Rossana Roncato, Volker M. Lauschke, Stefano Calza, Michele Spina, Fabio Puglisi, Giuseppe Toffoli, Erika Cecchin. “The DPYD rare and novel genetic variants burden predicts fluoropyrimidines-related severe toxicity” Journal Pharmacological Research under revision.