Abstract

Recent advances in immunology and genetics have clarified that the innate and adaptive immune response is equally important in the pathogenesis of the IBD. Two types of innate immune cells playing a role in IBDs are mast cells and macrophages, intestinal tissue-resident cells that exhibit an array of molecules involved in cell-cell, cell-extracellular matrix adhesion, mediating delivery of costimulatory signals that empower these cells with an ability to react to multiple nonspecific and specific stimuli. It has been shown for MCs, and it is emerging for MOs too, that they present different secretory phenotypes depending on the intensity/quality of the stimulus, training of the cells, and the integration of different signal transduction pathways. MS4A proteins are differentially expressed in leukocyte subsets, and their expression in different combinations might contribute to fine-tuning immune cell activation. MS4A proteins act as components of «sensing machineries» regulating cell activation by working as ion channels or by modulating the signaling of other immunoreceptors, including the B cell receptor, other immunoglobulin receptors, pattern recognition or triggering receptors.Among these proteins, MS4A4A has been identified in both human and murine M2-type macrophages, in tumor associated macrophages and in mast cells. The role of MS4A4A in IBD will be investigated by transcriptomic analysis of single cells isolated from intestinal inflamed tissue of MS4A KO mice or MC/macrophages deficient mice reconstituted with BMMC/BMDM from MS4A4 -/- mice.

Partenariato

• Università degli Studi di Udine
• Università degli Studi di Milano

Importo del progetto

Importo totale del progetto        Euro 146.075,00
Importo del progetto Uniud        Euro 110.000,00
Finanziamento Uniud                Euro 36.075,00

Durata

• Dal 28/09/2023
• Al 27/09/2025