Programma Corso integrato di Regenerative medicine
Denominazione insegnamento (in inglese)
REGENERATIVE MEDICINE.
Lingua dell’insegnamento
Inglese e italiano.
Crediti e ore di lezione
11 CFU (88 ore).
Moduli: sì.
Se sì, specificare denominazione
1) Stem Cells and Regenerative Medicine
Settore/i scientifico disciplinare
MED/08
Docente
Antonio Paolo Beltrami
Indirizzo email
antonio.beltrami@uniud.it
Pagina web personale
https://people.uniud.it/page/antonio.beltrami
2) Diagnostic and experimental technologies, nanotechnologies
Settore/i scientifico disciplinare
MED/08
Docente
Daniela Cesselli
Indirizzo email
3) Applicazioni mediche delle biotecnologie e della biologia artificiale
Settore/i scientifico disciplinare
MED/18
Docente
Umberto Baccarani
Indirizzo email
umberto.baccarani@uniud.it
PREREQUISITI E PROPEDEUTICITÀ |
Conoscenze di base di biologia cellulare e molecolare, Organ physiopathology, Epigenetics and stem cells. |
CONOSCENZE E ABILITÀ DA ACQUISIRE |
Objective of this series of lessons is to introduce students to the concepts of stem cells, tissue healing and regeneration. The first module will be specifically focused on the cardiovascular system and will discuss: the involvement of stem cells in cardiovascular development and physiology, the experimental use of stem cells for cardiovascular healing and regeneration, and clinical trials experimenting the use of stem cells for the treatment of acute and chronic heart disease. A particular emphasis will be given to review literature data, pointing out to seemingly divergent results. At the end of this module, students should be able to critically revise regenerative medicine studies trying to reconcile seemingly contrasting results or disproving them. Students that will develop a special interest in these branch of biotechnology, will be given the opportunity to perform supervised training in our research laboratories. The second module will illustrate how microscopy-, flow-cytometry-, cell separation-, cell culture-, and nanotechnological-techniques can impact both in research and diagnostic practice. At the end of this module, students must be able to chose among the different in vitro and in vivo assays the most proper for a specific experimental or diagnostic task. Additionally, they are required to understand the advantages and limits of each assay. Last, students will be introduced to a very relevant clinical issue related to organ transplantation, that is organ preservation, especially in the scenario of older and ‘higher risk’ donors. Specifically, at the end of this series of lectures, students must know the main mechanisms of organ injury associated with organ preservation and advanced methodologies that have been experimented to improve it. |
PROGRAMMA/CONTENUTI DELL’INSEGNAMENTO |
MODULO:
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ATTIVITÀ DI APPRENDIMENTO E METODI DIDATTICI PREVISTI |
This course will include both taught modules and laboratory practice. This latter will be aimed at showing how the competences acquired by the students need to integrate with specific technical skills to address specific, clinically relevant, questions. |
MODALITÀ DI VERIFICA DELL’APPRENDIMENTO |
The exam will be written, constituted part of multiple choice quizzes, part of open questions.
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TESTI/BIBLIOGRAFIA |
Students will be provided both of copy of the slides employed by the Lecturers, and of review and original papers that are considered of crucial importance. Those that are interested in further reading, may refer to “Principles of Regenerative Medicine” Author(s): Anthony Atala, MD, Robert Lanza, MD, James A. Thomson, PhD, and Robert M. Nerem, PhD ISBN: 978-0-12-369410-2. |