STIMOLA CURIOSITA’, PASSIONE E CORAGGIO
Identification of genetic and epigenetic regulators supervising R-loops formation
Abstract
R-loops were identified as the result of abortive transcripts accumulation, but more recently it has been demonstrated that they actively regulate transcription by serving both as platforms for the recruitment of transcription factors and terminators. Moreover R-loops can also form in trans independently from the transcription process and affect genome stability and DNA damage response (DDR). In this proposal we aim to identify new cis and trans regulators of R-loops and evaluate the direct impact of Rloops accumulation on genome stability and DSB repair.
Partenariato
- Università di Bologna
- Università degli Studi di Udine
- Università degli Studi di Milano-Bicocca
Importo del progetto
Importo totale del progetto Euro 249.500,00
Importo del progetto Uniud Euro 76.230,00
Finanziamento Uniud Euro 0
Durata
- Dal 28.09.2023
- Al 27.09.2025
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